Vitamin D Deficiency & Sleep Apnea – a Study

A study published in the February 2016 issue of SLEEP journal found that Serum Vitamin D is inversely associated with disease severity in Caucasian adults with Obstructive Sleep Apnea Syndrome

This was a cross-sectional study conducted at an urban, clinical sleep medicine outpatient center. 

106 adults (77 male; median age = 54.5; median BMI = 34.3 kg/m2) resident in Dublin, Ireland were recruited and categorized as non-OSAS or mild/moderate/severe OSAS. 98% of OSAS cases had insufficient vitamin D (< 75 nmol/L), including 72% with vitamin D (< 50 nmol/L). Vitamin D levels decreased with OSAS severity (P = 0.003). 

The researchers observed widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population. 

There were significant, independent, inverse relationships between 25(OH)D and AHI as well as nocturnal HR, a known cardiovascular risk factor. Further, 25(OH)D was significantly lower in OSAS cases compared to matched, non-OSAS subjects. 

The study demonstrates that 25(OH)D and OSAS are related, but the role, if any, of replenishment has not been investigated.